dc.contributor.advisor | Bravo Araujo, Gloria Tula | |
dc.contributor.author | Huaman Huaman ,Luz Marina | |
dc.contributor.author | Muñoz Quispe, Ruth Gabriela | |
dc.date.accessioned | 2024-04-04T15:55:58Z | |
dc.date.available | 2024-04-04T15:55:58Z | |
dc.date.issued | 2024-03-11 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12970/2036 | |
dc.description.abstract | Objetivo: evaluar la actividad antifúngica in vitro de extractos
etanólicos y metanólicos del rizoma de cúrcuma longa L. (stick) frente
a Cándida albicans ATCC 90028 y Aspergillus niger ATCC 6275.
Material y métodos: enfoque cuantitativo, diseño experimental,
transversal. Los extractos se obtuvieron mediante la técnica de
maceración; los cuales fueron tamizados fitoquímicamente para
comprobar la presencia de metabolitos secundarios. Se aplicó la
técnica de Kirby Bauer para evaluar la actividad antifúngica
trabajando extractos metanólicos y etanólicos en concentraciones de
25%, 50% y 75% sobre Cándida albicans ATCC 90028 y Aspergillus
niger ATCC 6275, y comparándolo con fluconazol como control.
Resultados: se encontraron antocianinas, alcaloides, lactonas,
taninos y fenoles en los extractos etanólico y metanólico de cúrcuma
longa L., así como una presencia moderada de flavonoides y una
ligera presencia de triterpenos. El extracto metanólico del rizoma de
cúrcuma longa L. (stick), en las concentraciones de 25%, 50% y 75%
para la cepa ATCC 90028 de Cándida albicans, tiene actividad
antifúngica de alta sensibilidad. El extracto etanólico del rizoma de
cúrcuma longa L. (stick), en las concentraciones de 25%, 50% y 75%
para la cepa ATCC 6275 de Aspergillus niger, tiene actividad
antifúngica extremadamente sensible, mientras que con Fluconazol
fue muy sensible para ambos extractos en el rango de 14,70 – 19,92
mm.
Conclusiones: extractos metanólicos y etanólicos del rizoma de
cúrcuma longa L. (stick) tienen actividad antifúngica in vitro
altamente sensible contra Cándida albicans ATCC 90028 y Aspergillus
niger ATCC 6275, respectivamente. | es_PE |
dc.description.abstract | Objective: to evaluate the in vitro antifungal activity of ethanolic
and methanolic extracts of the rhizome of Curcuma longa L. (stick)
against Candida albicans ATCC 90028 and Aspergillus niger ATCC
6275.
Material and methods: quantitative approach, experimental design,
cross-sectional. The extracts were obtained by means of the
maceration technique, which were phytochemically screened to
check the presence of secondary metabolites. Kirby Bauer's
technique was applied to evaluate the antifungal activity by working
methanolic and ethanolic extracts in concentrations of 25%, 50%,
and 75% on Candida albicans ATCC 90028 and Aspergillus niger ATCC
6275 and comparing it with fluconazole as a control.
Results: anthocyanins, alkaloids, lactones, tannins and phenols were
found in the ethanolic and methanolic extracts of Curcuma longa L.,
as well as a moderate presence of flavonoids and a slight presence
of triterpenes. The methanolic extract of the rhizome of Curcuma
longa L. (stick), in the concentrations of 25%, 50% and 75% for the
Candida albicans strain ATCC 90028, has highly sensitive antifungal
activity. The ethanolic extract of the rhizome of Curcuma longa L.
(stick), in the concentrations of 25%, 50% and 75% for the Aspergillus
niger strain ATCC 6275, has extremely sensitive antifungal activity,
while with Fluconazole it was very sensitive for both extracts in the
range of 14.70 – 19.92
mm.
Conclusions: methanolic and ethanolic extracts of the rhizome of
Curcuma longaL. (stick) have highly sensitive antifungal activity in
vitro against Candida albicans ATCC 90028 and Aspergillus niger
ATCC 6275 respectively. | es_PE |
dc.format | application/pdf | es_PE |
dc.language.iso | spa | es_PE |
dc.publisher | Universidad María Auxiliadora | es_PE |
dc.rights | info:eu-repo/semantics/openAccess | es_PE |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | es_PE |
dc.subject | Cándida albicans ATCC 90028 | es_PE |
dc.subject | Aspergillus niger ATCC 6275 | es_PE |
dc.subject | Extractos alcohólicos | es_PE |
dc.subject | Actividad antifúngica | es_PE |
dc.subject | Cúrcuma longa L. | es_PE |
dc.subject | Alcoholic extracts | es_PE |
dc.subject | Antifungal activity | es_PE |
dc.title | Actividad antifúngica in vitro de los extractos etanólico y metanólico de rizoma de cúrcuma longa l. (palillo), frente a Cándida Albicans ATCC 90028 y aspergillus niger ATCC 6275 | es_PE |
dc.title.alternative | In vitro antifungal activity of extracts ethanolic and methanolic from the rhizome of Curcuma longa L. (Stick), in front of Candida Albicans ATCC 90028 and aspergillus niger ATCC 6275 | es_PE |
dc.type | info:eu-repo/semantics/bachelorThesis | es_PE |
dc.publisher.country | PE | es_PE |
dc.subject.ocde | https://purl.org/pe-repo/ocde/ford#3.01.05 | es_PE |
dc.type.version | info:eu-repo/semantics/acceptedVersion | es_PE |
thesis.degree.discipline | Farmacia y Bioquímica | es_PE |
thesis.degree.grantor | Universidad María Auxiliadora. Facultad de Ciencias de la Salud. | es_PE |
thesis.degree.name | Químico Farmacéutico | es_PE |
renati.advisor.dni | 40863215 | |
renati.advisor.orcid | https://orcid.org/0000-0002-8133-3370 | es_PE |
renati.author.dni | 46527071 | |
renati.author.dni | 71810333 | |
renati.discipline | 917046 | es_PE |
renati.juror | La Serna La Rosa, Pablo Antonio | |
renati.juror | Siancas Tao, Norio Salvador | |
renati.juror | Dionicio Escalante, Elisa Roxana | |
renati.level | https://purl.org/pe-repo/renati/level#tituloProfesional | es_PE |
renati.type | https://purl.org/pe-repo/renati/type#tesis | es_PE |