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dc.contributor.advisorBravo Araujo, Gloria Tula
dc.contributor.authorHuaman Huaman ,Luz Marina
dc.contributor.authorMuñoz Quispe, Ruth Gabriela
dc.date.accessioned2024-04-04T15:55:58Z
dc.date.available2024-04-04T15:55:58Z
dc.date.issued2024-03-11
dc.identifier.urihttps://hdl.handle.net/20.500.12970/2036
dc.description.abstractObjetivo: evaluar la actividad antifúngica in vitro de extractos etanólicos y metanólicos del rizoma de cúrcuma longa L. (stick) frente a Cándida albicans ATCC 90028 y Aspergillus niger ATCC 6275. Material y métodos: enfoque cuantitativo, diseño experimental, transversal. Los extractos se obtuvieron mediante la técnica de maceración; los cuales fueron tamizados fitoquímicamente para comprobar la presencia de metabolitos secundarios. Se aplicó la técnica de Kirby Bauer para evaluar la actividad antifúngica trabajando extractos metanólicos y etanólicos en concentraciones de 25%, 50% y 75% sobre Cándida albicans ATCC 90028 y Aspergillus niger ATCC 6275, y comparándolo con fluconazol como control. Resultados: se encontraron antocianinas, alcaloides, lactonas, taninos y fenoles en los extractos etanólico y metanólico de cúrcuma longa L., así como una presencia moderada de flavonoides y una ligera presencia de triterpenos. El extracto metanólico del rizoma de cúrcuma longa L. (stick), en las concentraciones de 25%, 50% y 75% para la cepa ATCC 90028 de Cándida albicans, tiene actividad antifúngica de alta sensibilidad. El extracto etanólico del rizoma de cúrcuma longa L. (stick), en las concentraciones de 25%, 50% y 75% para la cepa ATCC 6275 de Aspergillus niger, tiene actividad antifúngica extremadamente sensible, mientras que con Fluconazol fue muy sensible para ambos extractos en el rango de 14,70 – 19,92 mm. Conclusiones: extractos metanólicos y etanólicos del rizoma de cúrcuma longa L. (stick) tienen actividad antifúngica in vitro altamente sensible contra Cándida albicans ATCC 90028 y Aspergillus niger ATCC 6275, respectivamente.es_PE
dc.description.abstractObjective: to evaluate the in vitro antifungal activity of ethanolic and methanolic extracts of the rhizome of Curcuma longa L. (stick) against Candida albicans ATCC 90028 and Aspergillus niger ATCC 6275. Material and methods: quantitative approach, experimental design, cross-sectional. The extracts were obtained by means of the maceration technique, which were phytochemically screened to check the presence of secondary metabolites. Kirby Bauer's technique was applied to evaluate the antifungal activity by working methanolic and ethanolic extracts in concentrations of 25%, 50%, and 75% on Candida albicans ATCC 90028 and Aspergillus niger ATCC 6275 and comparing it with fluconazole as a control. Results: anthocyanins, alkaloids, lactones, tannins and phenols were found in the ethanolic and methanolic extracts of Curcuma longa L., as well as a moderate presence of flavonoids and a slight presence of triterpenes. The methanolic extract of the rhizome of Curcuma longa L. (stick), in the concentrations of 25%, 50% and 75% for the Candida albicans strain ATCC 90028, has highly sensitive antifungal activity. The ethanolic extract of the rhizome of Curcuma longa L. (stick), in the concentrations of 25%, 50% and 75% for the Aspergillus niger strain ATCC 6275, has extremely sensitive antifungal activity, while with Fluconazole it was very sensitive for both extracts in the range of 14.70 – 19.92 mm. Conclusions: methanolic and ethanolic extracts of the rhizome of Curcuma longaL. (stick) have highly sensitive antifungal activity in vitro against Candida albicans ATCC 90028 and Aspergillus niger ATCC 6275 respectively.es_PE
dc.formatapplication/pdfes_PE
dc.language.isospaes_PE
dc.publisherUniversidad María Auxiliadoraes_PE
dc.rightsinfo:eu-repo/semantics/openAccesses_PE
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/es_PE
dc.subjectCándida albicans ATCC 90028es_PE
dc.subjectAspergillus niger ATCC 6275es_PE
dc.subjectExtractos alcohólicoses_PE
dc.subjectActividad antifúngicaes_PE
dc.subjectCúrcuma longa L.es_PE
dc.subjectAlcoholic extractses_PE
dc.subjectAntifungal activityes_PE
dc.titleActividad antifúngica in vitro de los extractos etanólico y metanólico de rizoma de cúrcuma longa l. (palillo), frente a Cándida Albicans ATCC 90028 y aspergillus niger ATCC 6275es_PE
dc.title.alternativeIn vitro antifungal activity of extracts ethanolic and methanolic from the rhizome of Curcuma longa L. (Stick), in front of Candida Albicans ATCC 90028 and aspergillus niger ATCC 6275es_PE
dc.typeinfo:eu-repo/semantics/bachelorThesises_PE
dc.publisher.countryPEes_PE
dc.subject.ocdehttps://purl.org/pe-repo/ocde/ford#3.01.05es_PE
dc.type.versioninfo:eu-repo/semantics/acceptedVersiones_PE
thesis.degree.disciplineFarmacia y Bioquímicaes_PE
thesis.degree.grantorUniversidad María Auxiliadora. Facultad de Ciencias de la Salud.es_PE
thesis.degree.nameQuímico Farmacéuticoes_PE
renati.advisor.dni40863215
renati.advisor.orcidhttps://orcid.org/0000-0002-8133-3370es_PE
renati.author.dni46527071
renati.author.dni71810333
renati.discipline917046es_PE
renati.jurorLa Serna La Rosa, Pablo Antonio
renati.jurorSiancas Tao, Norio Salvador
renati.jurorDionicio Escalante, Elisa Roxana
renati.levelhttps://purl.org/pe-repo/renati/nivel#tituloProfesionales_PE
renati.typehttps://purl.org/pe-repo/renati/type#tesises_PE


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